Purified Anti-Human CD146 Antibody[AA98]

SKU: GBS-F14170P

Size:1mg

Storage:Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Flow Cytometry Antibodies

Abbreviation:CD146

Target Synonym:MUC;cell surface glycoprotein MUC;MCAM;CD146;MUC18;cell surface glycoprotein MUC18; S-endo; MCAM; Mel-CAM; Endo-CAM;CD146;cell surface glycoprotein MUC18;MUC18;A32 antigen;CD 146;CD146 antigen;Cell surface glycoprotein P1H12;Gicerin;Melanoma adhesion molecule;Melanoma associated antigen A32;Melanoma associated antigen MUC18;Melanoma associated glycoprotein MUC18;melanoma cell adhesion molecule;Melanoma-associated antigen A32;Melanoma-associated antigen MUC18;MelCAM;MUC 18;S endo 1;S endo 1 endothelial associated antigen;S-endo 1 endothelial-associated antigen

Research Areas:Immunology;Signal Transduction;Cancer;Stem Cells;Cardiovascular

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:FCM

Usage:

Isotype:Mouse IgG2a, κ

Clonality:Monoclonal

Clone NO.:AA98

UNIProt ID:P43121

Background:Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Concentration: ≥ 1 mg/mL

Control catalog number:

Immunogen:Recombinant Human CD146 protein

Buffer:Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Purification method:>98%, Protein A/G purified

Dilution:FCM 2 μg/mL(0.5×10⁶-1×10⁶ cells)

GeneID:4162