PTPN22 Antibody - Cat. #: CSB-PA019036LA01HU

SKU: CSB-PA019036LA01HU

Size :50ul

Clone Number:

Aliases:Hematopoietic cell protein tyrosine phosphatase 70Z PEP antibody; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP antibody; Lymphoid phosphatase antibody; Lymphoid specific protein tyrosine phosphatase antibody; lymphoid-specific; inducible human protein tyrosine phosphatase antibody; Lyp 1 antibody; Lyp 2 antibody; LyP antibody; Lyp1 antibody; Lyp2 antibody; LyPTP antibody; OTTHUMP00000013720 antibody; OTTHUMP00000013721 antibody; OTTHUMP00000233450 antibody; OTTHUMP00000233451 antibody; PEP antibody; PEST-domain phosphatase antibody; Protein tyrosine phosphatase non receptor type 22 (lymphoid) antibody; Protein tyrosine phosphatase non receptor type 22 antibody; Protein tyrosine phosphatase non receptor type 8 antibody; Protein tyrosine phosphatase non receptor type 8; formerly antibody; PTN22_HUMAN antibody; PTPN 22 antibody; PTPN 8 antibody; Ptpn22 antibody; PTPN8 antibody; PTPN8; formerly antibody; Tyrosine-protein phosphatase non-receptor type 22 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y2R2

Immunogen:Recombinant Human Tyrosine-protein phosphatase non-receptor type 22 protein (1-179AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IF; Recommended dilution: IF:1:200-1:500

Background:Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating \'Tyr-394\' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating \'Tyr-493\' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PTPN22

Research Areas:Signal transduction