PTPN1 Monoclonal Antibody

SKU: BT-MCA2585

Size:100μL

Background:The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

Research_area:Signal Transduction

Target_protein:PTPN1

applications:WB, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:4F11B9

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:PTPN1

Immunogen:Purified recombinant fragment of human PTPN1 (AA: 40-246) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):50kDa

UniProt accession:P18031

Synonyms:PTP1B

GeneID:5770