PSTPIP1 Antibody - Cat. #: CSB-PA018944ESR1HU

SKU: CSB-PA018944ESR1HU

Size :50ul

Clone Number:

Aliases:CD2 antigen binding protein 1 antibody; CD2 binding protein 1 antibody; CD2 cytoplasmic tail binding protein antibody; CD2-binding protein 1 antibody; CD2BP1 antibody; CD2BP1L antibody; CD2BP1S antibody; H PIP antibody; H-PIP antibody; HPIP antibody; PAPAS antibody; PEST phosphatase interacting protein 1 antibody; PEST phosphatase-interacting protein 1 antibody; PPIP1_HUMAN antibody; Proline serine threonine phosphatase interacting protein 1 antibody; Proline-serine-threonine phosphatase-interacting protein 1 antibody; PSTPIP antibody; Pstpip1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O43586

Immunogen:Recombinant Human Proline-serine-threonine phosphatase-interacting protein 1 protein (157-416AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; Recommended dilution: WB:1:1000-1:5000

Background:Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PSTPIP1

Research Areas:Signal transduction