Proteinase 3 Monoclonal Antibody

SKU: BT-MCA3445

Size:100μL

Background:Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

Research_area:Others

Target_protein:Proteinase 3

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:3B4

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:Proteinase 3

Immunogen:Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):28kDa

UniProt accession:P24158

Synonyms:PRTN3, ACPA, CANCA

GeneID:5657