PPP1CC Antibody, Biotin conjugated - Cat. #: CSB-PA018505LD01HU

SKU: CSB-PA018505LD01HU

Size :50ug

Clone Number:

Aliases:PP 1G antibody; PP-1G antibody; PP1C antibody; PP1G antibody; PP1G_HUMAN antibody; PP1gamma antibody; PPP 1G antibody; PPP1CC antibody; PPP1G antibody; Protein phosphatase 1; catalytic subunit; gamma isozyme antibody; Protein phosphatase 1C catalytic subunit antibody; Serine/threonine phosphatase 1 gamma antibody; Serine/threonine protein phosphatase PP1 gamma catalytic subunit antibody; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P36873

Immunogen:Recombinant Human Serine/threonine-protein phosphatase PP1-gamma catalytic subunit protein (151-323AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the \'Ser-418\' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PPP1CC

Research Areas:Neuroscience; Cancer; Cell biology; Metabolism