PIK3CA Monoclonal Antibody

SKU: BT-MCA4236

Size:100μL

Background:PIK3CA is the most mutated gene in breast cancer and is important in other cancers. An integral part of the PI3K pathway, PIK3CA is an oncogene with two hotspots for activating mutations: the 542/545 region of the helical domain and the 1047 region of the kinase domain. The interaction of PIK3CA with the AKT and mTOR pathways is the subject of an immense amount of research and development, and PI3K inhibitors have exhibited some success in recent clinical trials. While PI3K monotherapies are likely insufficient, there is interest in pursuing PI3K inhibition in combination with other therapies including TKI's, MEK inhibitors, PARP inhibitors, and - in breast cancer - aromatase inhibitors.

Research_area:Signal Transduction

Target_protein:PIK3CA

applications:IHC, ICC, FCM

Reactivity:Human, Mouse, Rat, Rabbit

Clonality:Monoclonal

Clone ID:7H9B3

Host:Mouse

Isotype:Mouse IgG2a

Gene Symbol/ Name:PIK3CA

Immunogen:

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):124kDa

UniProt accession:P42336

Synonyms:PI3K, p110-alpha

GeneID: