PIAS2 Antibody - Cat. #: CSB-PA546547

SKU: CSB-PA546547

Size :100ul

Clone Number:

Aliases:Androgen receptor interacting protein 3 antibody; Androgen receptor-interacting protein 3 antibody; ARIP3 antibody; DAB2 interacting protein antibody; DAB2-interacting protein antibody; DIP antibody; E3 SUMO protein ligase PIAS2 antibody; E3 SUMO-protein ligase PIAS2 antibody; MIZ antibody; Miz1 antibody; Msx interacting zinc finger protein antibody; Msx-interacting zinc finger protein antibody; PIAS NY protein antibody; PIAS-NY protein antibody; PIAS2 antibody; PIAS2_HUMAN antibody; PIASX antibody; PIASX-ALPHA antibody; PIASX-BETA antibody; Protein inhibitor of activated STAT x antibody; Protein inhibitor of activated STAT, 2 antibody; Protein inhibitor of activated STAT2 antibody; SIZ2 antibody; Zinc finger, MIZ-type containing 4 antibody; ZMIZ4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75928

Immunogen:Synthesized peptide derived from Internal of Human PIAS2.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.

Christina-Maria Hecker, J. Biol. Chem., Jun 2006; 281: 16117 - 16127.
Daria Donati, J. Immunol., SepHeitham Hassoun, 2006; 177: 3035 - 3044.
Heitham Hassoun, Am J Physiol Renal Physiol, Feb 2007; 10.1152.
David J. Sharkey, Mol. Hum. Reprod., Jul 2007;

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PIAS2

Research Areas:Epigenetics and Nuclear Signaling;Cell biology