Phospho-ROCK2 (Tyr722) Antibody - Cat. #: CSB-PA035451

SKU: CSB-PA035451

Size :100ul

Clone Number:

Aliases:coiled-coil-containing protein kinase 2 antibody; KIAA0619 antibody; p164 ROCK 2 antibody; p164 ROCK-2 antibody; Rho associated coiled coil containing protein kinase 2 antibody; Rho associated protein kinase 2 antibody; Rho associated; coiled coil containing protein kinase II antibody; Rho kinase 2 antibody; Rho-associated antibody; Rho-associated protein kinase 2 antibody; ROCK 2 antibody; Rock II antibody; Rock2 antibody; ROCK2_HUMAN antibody; Rock2m antibody; ROK alpha antibody; ROKalpha antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75116

Immunogen:Peptide sequence around phosphorylation site of Tyrosine 722(K-I-Y(p)-E-S) derived from Human ROCK2.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ROCK2

Research Areas:Cancer;Cell biology;Signal transduction