Phospho-EPOR (Tyr368) Antibody - Cat. #: CSB-PA598485

SKU: CSB-PA598485

Size :100ul

Clone Number:

Aliases:EPO R antibody; EPO Receptor antibody; EPO-R antibody; epor antibody; EPOR_HUMAN antibody; Erythropoietin receptor antibody; Erythropoietin receptor precursor antibody; MGC138358 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P19235

Immunogen:Peptide sequence around phosphorylation site of Tyrosine 368 (D-T-Y(p)-L-V) derived from Human Epo-R.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.

Funakoshi-Tago M, et al. (2010) J Biol Chem 285, 5296-307
Sulahian R, Cleaver O, Huang LJ (2009) Blood 113, 5287-97
Zhang YL, et al. (2009) Mol Cell 33, 266-74

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:EPOR

Research Areas:Cardiovascular;Immunology;Signal transduction?Stem cells