PEPC (Phospho Ser15) rabbit pAb

SKU: ES20563

Size: 100μL

Source:Rabbit

Applications:WB; ELISA;IHC

Reactivity:Plants

Dilution:WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

Immunogen:Synthetic Peptide of PEPC (Phospho Ser15)

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:

Observed_band(KD):105-110kD

Human_gene_id:5225

Human_swiss_prot_no:P20142

Subcellular_location:Secreted.

Other_name:PGC; Gastricsin; Pepsinogen C

Background:This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009],