PDGFRB (Ab-751) Antibody - Cat. #: CSB-PA828739

SKU: CSB-PA828739

Size :100ul

Clone Number:

Aliases:Beta platelet derived growth factor receptor antibody; Beta-type platelet-derived growth factor receptor antibody; CD 140B antibody; CD140 antigen-like family member B antibody; CD140b antibody; CD140b antigen antibody; IBGC4 antibody; IMF1 antibody; JTK12 antibody; OTTHUMP00000160528 antibody; PDGF R beta antibody; PDGF Receptor beta antibody; PDGF-R-beta antibody; PDGFR 1 antibody; PDGFR antibody; PDGFR beta antibody; PDGFR1 antibody; PDGFRB antibody; PGFRB_HUMAN antibody; Platelet derived growth factor receptor 1 antibody; Platelet derived growth factor receptor beta antibody; Platelet derived growth factor receptor beta polypeptide antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P09619

Immunogen:Peptide sequence around aa.749~753 (V-D-Y-V-P) derived from Human PDGFRb.

Raised in:Rabbit

Species Reactivity:Human, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

PDGF Receptor b encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor a and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Lederle W, et al. (2006) Am J Pathol ; 169(5): 1767-1783.
Vignais ML, et al. (1999) Mol Cell Biol; 19(5): 3727-3735.
Herrlich A, et al. (1998) Proc Natl Acad Sci U S A; 95(15): 8985-8990.
Heuchel R, et al. (1999) Proc Natl Acad Sci U S A; 96(20): 11410-11415.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PDGFRB

Research Areas:Cancer?Cardiovascular;Signal transduction