PARN antibody , Cat. # FNab06150

SKU: FNab06150

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)

Background:The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen:poly(A)-specific ribonuclease (deadenylation nuclease)

Synonyms:DAN

Observed MW:90 kDa

Uniprot ID:O95453

Reactivity:Human

Tested Application:ELISA, WB, IHC

Recommended dilution:WB: 1:1000 - 1:3000; IHC: 1:50 - 1:200

Gene ID:5073

Research Area:Metabolism