PARK7 Antibody - Cat. #: CSB-PA03724A0Rb

SKU: CSB-PA03724A0Rb

Size :50ug

Clone Number:

Aliases:CAP1 antibody; DJ-1 antibody; DJ1 antibody; DJ1 protein antibody; Epididymis secretory sperm binding protein Li 67p antibody; FLJ27376 antibody; FLJ34360 antibody; FLJ92274 antibody; HEL S 67p antibody; Oncogene DJ1 antibody; OTTHUMP00000001348 antibody; OTTHUMP00000001349 antibody; OTTHUMP00000001350 antibody; OTTHUMP00000001351 antibody; PARK7 antibody; PARK7_HUMAN antibody; Parkinson disease (autosomal recessive, early onset) 7 antibody; Parkinson disease protein 7 antibody; Parkinson protein 7 antibody; Protein DJ-1 antibody; SP22 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q99497

Immunogen:Recombinant Human Protein DJ-1 protein (1-188AA)

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background:PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies (Rizzu et al. 2004). Defects in PARK7/DJ1 are the cause of autosomal recessive early-onset Parkinson\'s disease 7 (PARK7). Parkinson\'s disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PARK7

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Metabolism; Signal transduction