Outer capsid protein VP4 Antibody, Biotin conjugated - Cat. #: CSB-PA320838LD01ROH

SKU: CSB-PA320838LD01ROH

Size :50ug

Clone Number:

Aliases:antibody; Outer capsid protein VP4 antibody; Hemagglutinin) [Cleaved into: Outer capsid protein VP8*; Outer capsid protein VP5*] antibody

Product Type:Polyclonal Antibody

Immunogen Species:Rotavirus A (strain RVA/Homo sapiens (Human)/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) (Rotavirus A (strain St. Thomas 3))

UniProt ID:P11200

Immunogen:Recombinant Rotavirus A Outer capsid protein VP4 protein (247-479AA)

Raised in:Rabbit

Species Reactivity:Rotavirus A

Tested Applications:ELISA

Background:Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. According to the considered strain, VP4 seems to essentially target sialic acid and/or the integrin heterodimer ITGA2/ITGB1 (By similarity).By similarity Outer capsid protein VP5*: forms the spike \"foot\" and \"body\". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment (By similarity).By similarity VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:

Research Areas:Others