OGG1 Polyclonal Antibody

SKU: BT-AP12189

Size:100μL

Background:This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.

Research_area:Cancer; Epigenetics and nuclear signaling

Target_protein:OGG1

applications:WB, ELISA

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: O15527; Mouse: O08760; Rat: O70249

Synonyms:N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase ;EC 3.2.2.-; DNA-;apurinic or apyrimidinic site lyase ;AP lyase;EC 4.2.99.18]

GeneID:Human: 4968