Nuclear Receptor NR4A1 (Phospho-Ser351) Rabbit pAb

SKU: ES14439

Size: 100μL

Source:Rabbit

Applications:WB; ELISA

Reactivity:Human; Mouse; Rat

Dilution:WB 1:500-2000, ELISA(peptide)1:5000-20000

Immunogen:Synthesized pospho peptide derived from human Nuclear Receptor NR4A1 (Phospho-Ser351)

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):77kD

Human_gene_id:3164

Human_swiss_prot_no:P22736

Subcellular_location:Nucleus . Cytoplasm . Mitochondrion . Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). .

Other_name:Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1;Nuclear hormone receptor NUR/77;Nur77;Orphan nuclear receptor HMR;Orphan nuclear receptor TR3;ST-59;Testicular receptor 3)

Background:This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],