NIPBL Polyclonal Antibody

SKU: E-AB-18915

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: NIPBL

Target Synonym: CDLS;Colon tumor susceptibility 2;Delangin;DKFZp434L1319;FLJ11203;FLJ12597;FLJ13354;FLJ13648;FLJ44854;IDN 3;IDN 3 protein;IDN 3 protein isoform A;IDN 3 protein isoform B;IDN 3B;IDN3 B;IDN3 protein;IDN3 protein isoform A;IDN3 protein isoform B;IDN3B;Mis 4;Mis4;Nipbl;NIPBL;Nipped B homolog (Drosophila);Nipped B homolog;Nipped B like;Nipped B like protein;Nipped-B-like protein;Scc 2;SCC 2 homolog;Scc2;SCC2 homolog;Sister chromatid cohesion protein Mis4

Research Areas: Cancer;Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q6KC79

Accession:

Background: This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene.

Concentration: 0.9 mg/mL

Immunogen: Fusion protein of human NIPBL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:50-1:200

Calculated MW:

ObservedMW: