NF2(Phospho Ser518) Polyclonal Antibody

SKU: BT-AP09071

Size:100μL

Background:This gene encodes a protein that is similar to some members of the ERM (ezrin| radixin| moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins| proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults| significant expression is found in Schwann cells| meningeal cells| lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

Research_area:Cancer; Epigenetics and nuclear signaling; Neuroscience; Signal transduction

Target_protein:NF2

applications:WB, IHC-p, IF, ICC, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Merlin

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):69690

UniProt accession:Human: P35240; Mouse: P46662; Rat: Q63648

Synonyms:Merlin; NF2; SCH; Merlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin

GeneID:Human: 4771; Mouse: 18016; Rat: 25744