NEDD8 Antibody - Cat. #: CSB-PA053660

SKU: CSB-PA053660

Size :100ul

Clone Number:

Aliases:FLJ43224 antibody; MGC104393 antibody; MGC125896 antibody; MGC125897 antibody; NED8 antibody; NEDD 8 antibody; NEDD-8 antibody; Nedd8 antibody; NEDD8_HUMAN antibody; Neddylin antibody; Neural precursor cell expressed developmentally down regulated 8 antibody; Neural precursor cell expressed developmentally down regulated gene 8 antibody; Neural precursor cell expressed developmentally down-regulated protein 8 antibody; Rub1 antibody; Ubiquitin like protein Nedd 8 antibody; Ubiquitin like protein Nedd8 antibody; Ubiquitin-like protein Nedd8 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q15843

Immunogen:Synthesized peptide derived from Internal of Human NEDD8.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Margaret A. Read, Mol. Cell. Biol., Apr 2000; 20: 2326 - 2333.
Kenneth Wu, J. Biol. Chem., Aug 2003; 278: 28882 - 28891.
Katsumi Kito, J. Biol. Chem., Jun 2001; 276: 20603 - 20609.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NEDD8

Research Areas:Cell biology