NDUFA1 Rabbit pAb

SKU: ES14533

Size: 100μL

Source:Rabbit

Applications:IHC; ELISA

Reactivity:Human; Mouse; Rat

Dilution:IHC-p 1:50-200, ELISA(peptide)1:5000-20000

Immunogen:Synthesized peptide derived from human NDUFA1 AA range: 20-100

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:4694

Human_swiss_prot_no:O15239

Subcellular_location:Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side .

Other_name:NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Complex I-MWFE;CI-MWFE;NADH-ubiquinone oxidoreductase MWFE subunit)

Background:The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008],