MYPT1(Phospho-Ser668) Rabbit Polyclonal Antibody

SKU: BT-AP11473

Size:100μL

Background:Myosin phosphatase target subunit 1| which is also called the myosin-binding subunit of myosin phosphatase| is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation| which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound| active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase| which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase)| which is activated by GTP. RhoA| phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosph

Research_area:Epigenetics and nuclear signaling; Signal transduction

Target_protein:PPP1R12A

applications:WB

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:MYPT1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: O14974; Mouse: Q9DBR7; Rat: Q10728

Synonyms:MYPT1 ;Ser668; Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase-targeting subunit 1; Myosin phosphatase target subunit 1; Protein phosphatase myosin-binding subunit

GeneID:Human: 4659; Mouse: 17931; Rat: 116670