MRE11 Monoclonal Antibody

SKU: BT-MCA4568

Size:100μL

Background:This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Research_area:Others

Target_protein:MRE11

applications:WB, IHC, FCM

Reactivity:Human, Mouse, Monkey, Rat

Clonality:Monoclonal

Clone ID:7C8A9

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:MRE11

Immunogen:Purified recombinant fragment of human MRE11 (AA: 182-582) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):80.6kDa

UniProt accession:P49959

Synonyms:ATLD, HNGS1, MRE11A, MRE11B

GeneID:4361