Mouse Ubiquitin-like Modifier-activating Enzyme 1, UBA1 ELISA Kit

SKU: E2551Mo

Size:96 Tests-1 Kit

Background:Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1511901). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.

Research_area:Cell Biology

Applications:ELISA

Target_protein:UBA1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:1.66ng/L

Detection range:3-900ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Ubiquitin-like modifier-activating enzyme 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q02053

MASS(Da):117,809

GeneID:22201

Synonyms:A1;A1S9;Sb;Sbx;UBA1;Ube-1;Ube1x;Ubiquitin-activating enzyme E1;Ubiquitin-activating enzyme E1 X;Ubiquitin-like modifier-activating enzyme 1;Ubiquitin-like modifier-activating enzyme 1 X

Gene names:Uba1

Standard solution:960ng/L