Mouse Toll-like Receptor 8, TLR8 ELISA Kit

SKU: E2516Mo

Size:96 Tests-1 Kit

Background:Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively.

Research_area:Immunology; Microbiology

Applications:ELISA

Target_protein:TLR8

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:1.55ng/L

Detection range:3-900ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Toll-Like Receptor 8

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P58682

MASS(Da):119,358

GeneID:170744

Synonyms:CD antigen CD288;TLR 8;TLR8;Toll-like receptor 8

Gene names:TLR8

Standard solution:960ng/L