Mouse Secretory Phospholipase A2 Receptor, PLA2R1 ELISA Kit

SKU: E2444Mo

Size:96 Tests-1 Kit

Background:Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10. In podocytes, binding of sPLA2-IB/PLA2G1B can regulate podocyte survival and glomerular homeostasis.

Research_area:Cardiovascular

Applications:ELISA

Target_protein:PLA2R1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.024ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Secretory Phospholipase A2 Receptor

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q62028

MASS(Da):170,512

GeneID:18779

Synonyms:180 kDa secretory phospholipase A2 receptor;M-type receptor;PLA 2R1;PLA2R;PLA2-R;PLA2R1;Secretory phospholipase A2 receptor;Soluble PLA2R;Soluble PLA2-R;Soluble secretory phospholipase A2 receptor

Gene names:PLA2R1

Standard solution:24ng/mL