Mouse Receptor-type tyrosine-protein phosphatase beta,PTPRB ELISA KIT

SKU: E1085Mo

Size:96 Tests-1 Kit

Background:Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. {ECO:0000269|PubMed:10557082, ECO:0000269|PubMed:12234928, ECO:0000269|PubMed:16514057, ECO:0000269|PubMed:17360632, ECO:0000269|PubMed:19015309, ECO:0000269|PubMed:19451274}.

Research_area:

Applications:ELISA

Target_protein:Ptprb

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.08ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Protein Tyrosine Phosphatase Receptor Type B

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:B2RU80

MASS(Da):224495

GeneID:19263

Synonyms:Ptprb

Gene names:Ptprb

Standard solution:24ng/ml