Mouse Nucleotide-binding Oligomerization Domain-containing Protein 2, NOD2 ELISA Kit

SKU: E2317Mo

Size:96 Tests-1 Kit

Background:Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (PubMed:22607974). Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1. Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon.

Research_area:Others

Applications:ELISA

Target_protein:NOD2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:4.96ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Nucleotide-binding oligomerization domain-containing protein 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8K3Z0

MASS(Da):113,562

GeneID:257632

Synonyms:ACUG;BLAU;Card;Card15;Caspase recruitment domain-containing protein 15;CD;F830032C23Rik;IBD1;Nl;NOD2;Nucleotide-binding oligomerization domain-containing protein 2

Gene names:Nod2

Standard solution:2400ng/L