Mouse Nerve growth factor,NGF ELISA KIT

SKU: E0081Mo

Size:96 Tests-1 Kit

Background:Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:20036257). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:22649032). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786). In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (PubMed:20036257). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer (PubMed:22649032, PubMed:26144237). The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (PubMed:22649032). {ECO:0000250|UniProtKB:P01138, ECO:0000269|PubMed:20036257, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:22649032, ECO:0000269|PubMed:26144237}.

Research_area:

Applications:ELISA

Target_protein:Ngf

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.26ng/ml

Detection range:0.5-90ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Nerve growth factor

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P01139

MASS(Da):27077

GeneID:18049

Synonyms:Ngf Ngfb

Gene names:Ngf

Standard solution:96ng/ml