Mouse Myelin associated glycoprotein,MAG ELISA KIT

SKU: E1389Mo

Size:96 Tests-1 Kit

Background:Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (PubMed:7533044, PubMed:12089450, PubMed:27922006). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination (PubMed:7516497, PubMed:9262180, PubMed:9482781, PubMed:9482783, PubMed:9469574, PubMed:10625334). Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2 (PubMed:26335717). Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (PubMed:15953602, PubMed:19158290). Negative regulator of neurite outgrowth that inhibits axon longitudinal growth (PubMed:19158290, PubMed:27922006, PubMed:12089450). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides (PubMed:17640868). In cerebellar granule cells the inhibition is mediated via binding to neuronal gangliosides (PubMed:17640868). In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (By similarity). Inhibits axon outgrowth by binding to RTN4R (PubMed:12089450). Preferentially binds to alpha-2,3-linked sialic acid (PubMed:7533044, PubMed:27922006). Binds ganglioside Gt1b (PubMed:27922006). {ECO:0000250|UniProtKB:P07722, ECO:0000269|PubMed:10625334, ECO:0000269|PubMed:12089450, ECO:0000269|PubMed:15953602, ECO:0000269|PubMed:17640868, ECO:0000269|PubMed:19158290, ECO:0000269|PubMed:26335717, ECO:0000269|PubMed:27922006, ECO:0000269|PubMed:7516497, ECO:0000269|PubMed:7533044, ECO:0000269|PubMed:9262180, ECO:0000269|PubMed:9469574, ECO:0000269|PubMed:9482781, ECO:0000269|PubMed:9482783}.

Research_area:

Applications:ELISA

Target_protein:Mag

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.09ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Myelin associated glycoprotein

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P20917

MASS(Da):69388

GeneID:17136

Synonyms:Mag

Gene names:Mag

Standard solution:24ng/ml