Mouse Monocyte Differentiation Antigen Cd14, CD14 ELISA Kit

SKU: E2267Mo

Size:96 Tests-1 Kit

Background:Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed: 16148141). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed: 8612135, PubMed: 15895089). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (By similarity). Acts as an accessory receptor for M.tuberculosis lipoproteins LprA, LprG and LpqH, in conjunction with coreceptors TLR2 and TLR1. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed: 19362712). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).

Research_area:Immunology; Stem Cells

Applications:ELISA

Target_protein:CD14

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.021ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Monocyte Differentiation Antigen Cd14

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P10810

MASS(Da):39,204

GeneID:12475

Synonyms:CD 14;CD antigen CD14;CD14;LPS-R;Mo2;Monocyte differentiation antigen CD14;Myeloid cell-specific leucine-rich glycoprotein

Gene names:CD14

Standard solution:24ng/mL