Mouse Lysosome-associated Membrane Glycoprotein 2, LAMP2 ELISA Kit

SKU: E2227Mo

Size:96 Tests-1 Kit

Background:Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed: 10972293). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed: 27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed: 27628032). Required for normal degradation of the contents of autophagosomes (PubMed: 10972293, PubMed: 12221139). Plays a role in lysosomal protein degradation in response to starvation (PubMed: 27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic Peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits. Is not required for efficient MHCII-mediated presentation of endogenous antigens (By similarity).

Research_area:Cardiovascular

Applications:ELISA

Target_protein:LAMP2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.11ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Lysosome-Associated Membrane Glycoprotein 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P17047

MASS(Da):45,681

GeneID:16784

Synonyms:CD antigen CD107b;CD107 antigen-like family member B;LAMP 2;LAMP2;LAMP-2;LGP-B;Lysosomal membrane glycoprotein type B;Lysosome-associated membrane glycoprotein 2;Lysosome-associated membrane protein 2;

Gene names:LAMP2

Standard solution:4800ng/L