Mouse Interleukin-36 Beta, IL1F8 ELISA Kit

SKU: E2192Mo

Size:96 Tests-1 Kit

Background:Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial Peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1 (Th1) cells, cultured CD4(+) T-cells and splenocytes.

Research_area:Immunology

Applications:ELISA

Target_protein:IL36B

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:1.47ng/L

Detection range:3-900ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin-36 Beta

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9D6Z6

MASS(Da):20,878

GeneID:69677

Synonyms:IL 36B;IL-1F8;IL36B;Interleukin-1 family member 8;Interleukin-36 beta

Gene names:IL36B

Standard solution:960ng/L