Mouse Interferon Gamma Induced Protein 10kDa, IP10 ELISA Kit

SKU: E1731Mo

Size:96 Tests-1 Kit

Background:Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity) (PubMed: 28623423). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (PubMed: 18624292, PubMed: 19017990, PubMed: 28468883). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (PubMed: 15456824).

Research_area:Immunology; Microbiology; Cancer

Applications:ELISA

Target_protein:CXCL10

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:3.43ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interferon Gamma Induced Protein 10Kda

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P17515

MASS(Da):10,789

GeneID:15945

Synonyms:10 kDa interferon gamma-induced protein;C7;C-X-C motif chemokine 10;CXCL 10;CXCL10;Gamma-IP10;Interferon-gamma induced protein CRG-2;IP-10;Small-inducible cytokine B10;

Gene names:CXCL10

Standard solution:1600ng/L