Mouse Indoleamine 2, 3-dioxygenase 1, IDO1 ELISA Kit

SKU: E2147Mo

Size:96 Tests-1 Kit

Background:Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity (PubMed: 25691885). Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection (Ref. 3).

Research_area:Metabolism

Applications:ELISA

Target_protein:IDO1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:14.32ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Indoleamine 2,3-Dioxygenase 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P28776

MASS(Da):45,641

GeneID:15930

Synonyms:IDO 1;IDO1;IDO-1;Indoleamine 2,3-dioxygenase 1;Indoleamine-pyrrole 2,3-dioxygenase

Gene names:IDO1

Standard solution:9600ng/L