Mouse Granzymes B, GZMS-B ELISA Kit

SKU: E0437Mo

Size:96 Tests-1 Kit

Background:Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Research_area:Cell Biology

Applications:ELISA

Target_protein:GZMB

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:3.26ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Granzymes B

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P04187

MASS(Da):27,470

GeneID:14939

Synonyms:CCP1;CTLA-1;Cytotoxic cell protease 1;Fragmentin-2;Granzyme B(G,H;GZMB

Gene names:GZMB

Standard solution:1600ng/L