Mouse Glutamate, Nmda Receptor Subunit Epsilon-3, GRIN2C ELISA Kit

SKU: E2102Mo

Size:96 Tests-1 Kit

Background:Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:1377365). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:1377365). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex (PubMed:27922130). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:8987814).

Research_area:Neuroscience

Applications:ELISA

Target_protein:GRIN2C

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:4.45ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Glutamate,NMDA receptor subunit epsilon-3

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q01098

MASS(Da):135,420

GeneID:14813

Synonyms:GluN2C;Glutamate [NMDA] receptor subunit epsilon-3;Glutamate receptor ionotropic, NMDA 2C;GRIN2C;NMDA;NMDAR2C;N-methyl D-aspartate receptor subtype 2C;NR;NR2C;

Gene names:Grin2c

Standard solution:2400ng/L