Mouse Fractalkine,FKN;CX3CL1 ELISA KIT

SKU: E0046Mo

Size:96 Tests-1 Kit

Background:Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 (PubMed:10187784, PubMed:18971423). The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:10382755, PubMed:9177350, PubMed:10187784, PubMed:18971423). Regulates leukocyte adhesion and migration processes at the endothelium (PubMed:10382755, PubMed:9177350). Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner (By similarity). In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins (By similarity). In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (By similarity). {ECO:0000250|UniProtKB:P78423, ECO:0000269|PubMed:10187784, ECO:0000269|PubMed:10382755, ECO:0000269|PubMed:18971423, ECO:0000269|PubMed:9177350}.; [Processed fractalkine]: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. {ECO:0000250|UniProtKB:P78423}.; [Fractalkine]: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. {ECO:0000250|UniProtKB:P78423}.

Research_area:

Applications:ELISA

Target_protein:Cx3cl1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:1.95ng/ml

Detection range:3.75-240ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:CX3C-chemokine;Fractalkine

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O35188

MASS(Da):42099

GeneID:20312

Synonyms:Cx3cl1 Cx3c Fkn Scyd1

Gene names:Cx3cl1

Standard solution:480ng/ml