Mouse Ephrin Type-A Receptor 7, EPHA7 ELISA Kit

SKU: E2058Mo

Size:96 Tests-1 Kit

Background:Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties.

Research_area:Cardiovascular

Applications:ELISA

Target_protein:EPHA7

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.058ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Ephrin type-A receptor 7

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q61772

MASS(Da):111,860

GeneID:13841

Synonyms:Cek11;Developmental kinase 1;Ebk;Ehk3;EHK-3;Embryonic brain kinase;EPH homology kinase 3;EPHA7;Ephrin type-A receptor 7;Hek11;Mdk1;mDK-1

Gene names:Epha7

Standard solution:48ng/mL