Mouse Ephrin Type-A Receptor 2, EPHA2 ELISA Kit

SKU: E2057Mo

Size:96 Tests-1 Kit

Background:Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells (PubMed: 29749928). Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Research_area:Cardiovascular; Neuroscience

Applications:ELISA

Target_protein:EPHA2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:5.27ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Ephrin Type-A Receptor 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q03145

MASS(Da):108,852

GeneID:13836

Synonyms:CTPA;CTPP1;CTRCT6;EPHA 2;EPHA2;Ephrin type-A receptor 2;Epithelial cell kinase;MYK2;SEK2;Tyrosine-protein kinase receptor ECK;Tyrosine-protein kinase receptor MPK-5;Tyrosine-protein kinase receptor SEK-2

Gene names:EPHA2

Standard solution:2400ng/L