Mouse E3 Ubiquitin-protein Ligase Huwe1, HUWE1 ELISA Kit

SKU: E2034Mo

Size:96 Tests-1 Kit

Background:E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (By similarity). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of PA2G4 (By similarity). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:HUWE1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.11ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:E3 Ubiquitin-Protein Ligase HUWE1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q7TMY8

MASS(Da):482,635

GeneID:59026

Synonyms:E3 ubiquitin-protein ligase HUWE1;E3Histone;HECT, UBA and WWE domain-containing protein 1;HECT-type E3 ubiquitin transferase HUWE1;HUWE 1;HUWE1;Upstream regulatory element-binding protein 1;URE-B1;URE-binding protein 1;

Gene names:HUWE1

Standard solution:6400ng/L