Mouse DNA (cytosine-5)-methyltransferase 3A,DNMT3A ELISA KIT

SKU: E1445Mo

Size:96 Tests-1 Kit

Background:Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477). DNA methylation is coordinated with methylation of histones (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (PubMed:18823905). Plays a role in paternal and maternal imprinting (PubMed:15215868). Required for methylation of most imprinted loci in germ cells (PubMed:15215868). Acts as a transcriptional corepressor for ZBTB18 (PubMed:11350943). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (PubMed:20547484). Can actively repress transcription through the recruitment of HDAC activity (PubMed:11350943). Also has weak auto-methylation activity on Cys-706 in absence of DNA (PubMed:21481189). {ECO:0000269|PubMed:10555141, ECO:0000269|PubMed:11350943, ECO:0000269|PubMed:11399089, ECO:0000269|PubMed:11919202, ECO:0000269|PubMed:15215868, ECO:0000269|PubMed:16567415, ECO:0000269|PubMed:17713477, ECO:0000269|PubMed:18823905, ECO:0000269|PubMed:20547484, ECO:0000269|PubMed:21481189, ECO:0000269|PubMed:9662389}.

Research_area:

Applications:ELISA

Target_protein:Dnmt3a

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.046ng/ml

Detection range:0.1-38ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:DNA

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O88508

MASS(Da):101672

GeneID:13435

Synonyms:Dnmt3a

Gene names:Dnmt3a

Standard solution:40ng/ml