Mouse DLL4 ELISA Kit PicoKine®

SKU: EK1277

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: DLL4

Specificity: Natural and recombinant mouse DLL4

Background: Delta like ligand 4 is a protein that in humans is encoded by the DLL4 gene. It is mapped to 15q15.1. This gene is a homolog of the Drosophila delta gene. DLL4 is a transmembrane ligand for Notch receptors that shows restricted expression to endothelial cells (ECs), in particular to arteries and capillaries, and is involved in vascular development, and it also appeared to be a major trigger of Notch receptor activities previously implicated in arterial and vascular development. Mouse DLL4 could activate mouse Notch1 and mouse Notch4. DLL4 acts as a negative regulator of tumor angiogenesis, its blockade results in the striking uncoupling of tumor growth from vessel density, presenting a novel therapeutic approach even for tumors resistant to anti-VEGF therapies. In addition to it, this gene also plays an important role in promoting Th17 effector activity during mycobacterial challenge.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S28-P525

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Reconstitution:

Reference:

Uniprot ID: Q9JI71

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 54485

Protein Name: Delta-like protein 4

Gene Full Name: delta like canonical Notch ligand 4

Synonyms: Delta like protein 4; Delta4; DLL4; Drosophila Delta homolog 4; hdelta2