Mouse Disintegrin and Metalloproteinase Domain-containing Protein 15, ADAM15 ELISA Kit

SKU: E2025Mo

Size:96 Tests-1 Kit

Background:Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration (By similarity). Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Interactions with egg membrane could be mediated via binding between the disintegrin-like domain to one or more integrin receptors on the egg.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:ADAM15

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:5.19ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Disintegrin and metalloproteinase domain-containing protein 15

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O88839

MASS(Da):92,664

GeneID:11490

Synonyms:AD56;ADAM 15;ADAM15;Disintegrin and metalloproteinase domain-containing protein 15;MDC15;MDC-15;Metalloprotease RGD disintegrin protein;Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15;metar;Metargidin

Gene names:Adam15

Standard solution:2400ng/L