Mouse Cyclin-dependent kinase inhibitor 1,CDKN1A;P21 ELISA KIT

SKU: E1366Mo

Size:96 Tests-1 Kit

Background:May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (PubMed:25329316). Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity). Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity). {ECO:0000250|UniProtKB:P38936, ECO:0000269|PubMed:25329316}.

Research_area:

Applications:ELISA

Target_protein:Cdkn1a

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:13.93ng/L

Detection range:25-1600ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cyclin-dependent kinase inhibitor 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P39689

MASS(Da):17785

GeneID:12575

Synonyms:Cdkn1a Cip1 Waf1

Gene names:Cdkn1a

Standard solution:3200ng/L