Mouse Chemokine C-X-C-Motif Receptor 4,CXCR4 ELISA KIT

SKU: E1670Mo

Size:96 Tests-1 Kit

Background:Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:8962122, PubMed:9295051, PubMed:9103415). Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation (PubMed:9634237, PubMed:9634238, PubMed:9689100). Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (PubMed:9634237). Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (PubMed:9634238, PubMed:9689100). {ECO:0000250|UniProtKB:P61073, ECO:0000269|PubMed:8962122, ECO:0000269|PubMed:9103415, ECO:0000269|PubMed:9295051, ECO:0000269|PubMed:9634237, ECO:0000269|PubMed:9634238, ECO:0000269|PubMed:9689100}.

Research_area:

Applications:ELISA

Target_protein:Cxcr4

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Chemokine C-X-C-Motif Receptor 4

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P70658

MASS(Da):40426

GeneID:12767

Synonyms:Cxcr4 Cmkar4 Lestr Sdf1r

Gene names:Cxcr4

Standard solution:32ng/ml