Mouse CD22/Siglec 2 ELISA Kit PicoKine®

SKU: EK1303

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: CD22

Specificity: Natural and recombinant mouse CD22

Background: CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. This gene is mapped to 19q13.2. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. It is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling. This gene can downmodulate signaling through the IgM and IgD B-cell receptors (BCRs), but not through the IgG BCR, because the IgG cytoplasmic tail prevents CD22 phosphorylation and actually enhances IgG-BCR signaling.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S22-R702

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Reference:

Uniprot ID: P35329

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 12483

Protein Name: B-cell receptor CD22

Gene Full Name: CD22 antigen

Synonyms: B cell receptor CD22; BL CAM; CD22; CD22 molecule; SIGLEC 2; SIGLEC2; T cell surface antigen Leu 14