Mouse Beta-glucosidase,B-GLU ELISA KIT

SKU: E0746Mo

Size:96 Tests-1 Kit

Background:Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose (PubMed:24211208). Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation (By similarity). Also plays a role in cholesterol metabolism (PubMed:24211208). May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol (PubMed:24211208). The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction (By similarity). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (By similarity). Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol (By similarity). {ECO:0000250|UniProtKB:P04062, ECO:0000269|PubMed:24211208, ECO:0000269|PubMed:27378698}.

Research_area:

Applications:ELISA

Target_protein:Gba

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.155ng/ml

Detection range:0.3-90ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Glucosidase Beta

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P17439

MASS(Da):57622

GeneID:14466

Synonyms:Gba

Gene names:Gba

Standard solution:96ng/ml