Mouse antigen KI-67,MKI67 ELISA KIT

SKU: E1849Mo

Size:96 Tests-1 Kit

Background:Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (By similarity). Does not contribute to the internal structure of mitotic chromosomes (PubMed:26949251). May play a role in chromatin organization (PubMed:26949251). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed. {ECO:0000250|UniProtKB:P46013, ECO:0000269|PubMed:26949251, ECO:0000269|PubMed:27362226, ECO:0000305}.

Research_area:

Applications:ELISA

Target_protein:Mki67

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:5.16ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:antigen KI-67

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:E9PVX6

MASS(Da):350864

GeneID:17345

Synonyms:Mki67

Gene names:Mki67

Standard solution:2400ng/L