Mouse Aldose reductase,AKR1B1 ELISA KIT

SKU: E1828Mo

Size:96 Tests-1 Kit

Background:Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:17381426, PubMed:19010934, PubMed:7851421). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins (PubMed:19010934). Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (By similarity). {ECO:0000250|UniProtKB:P15121, ECO:0000269|PubMed:17381426, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:7851421}.

Research_area:

Applications:ELISA

Target_protein:Akr1b1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.022ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Aldose reductase

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P45376

MASS(Da):35732

GeneID:11677

Synonyms:Akr1b1 Akr1b3 Aldor1 Aldr1 Alr2

Gene names:Akr1b1

Standard solution:24ng/mL